| Identification | Back Directory | [Name]
PCA 50941 | [CAS]
136941-85-0 | [Synonyms]
PCA 50941
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-[(tetrahydro-2H-pyran-2-yl)methyl] ester | [Molecular Formula]
C30H31N3O10S | [MDL Number]
MFCD00905723 | [MOL File]
136941-85-0.mol | [Molecular Weight]
625.65 |
| Chemical Properties | Back Directory | [Boiling point ]
816.6±75.0 °C(Predicted) | [density ]
1.387±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
2.60±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease. | [in vivo]
PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals[2]. | [References]
[1] Montiel C, et al. Interactions between Ca2+, PCA50941 and Bay K 8644 in bovine chromaffin cells. Eur J Pharmacol. 1994 Aug 16;268(3):293-303. DOI:10.1016/0922-4106(94)90053-1
[2] Fernández N, et al. PCA50941, a new 1,4-dihydropyridine, reverses endothelin-induced cardiogenic shock in the anesthetized goat. Life Sci. 1998;62(21):1933-42. DOI:10.1016/s0024-3205(98)00162-3 |
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