| Identification | Back Directory | [Name]
4-Pyridinamine, 2,2'-(1,3-phenylene)bis- | [CAS]
1369963-51-8 | [Synonyms]
1,3-di(4-amino-2-pyridyl)benzene
4-Pyridinamine, 2,2'-(1,3-phenylene)bis- | [Molecular Formula]
C16H14N4 | [MOL File]
1369963-51-8.mol | [Molecular Weight]
262.31 |
| Chemical Properties | Back Directory | [Boiling point ]
597.6±50.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.22±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research[1]. | [References]
[1] SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024). DOI:10.1021/jacs.4c05623 |
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