| Identification | Back Directory | [Name]
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine | [CAS]
1371569-69-5 | [Synonyms]
BETP
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine
Pyrimidine, 2-(ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)- | [Molecular Formula]
C20H17F3N2O2S | [MDL Number]
MFCD23143626 | [MOL File]
1371569-69-5.mol | [Molecular Weight]
406.42 |
| Chemical Properties | Back Directory | [Boiling point ]
569.5±60.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
-5.23±0.50(Predicted) | [color ]
white to beige | [InChI]
1S/C20H17F3N2O2S/c1-2-28(26)19-24-17(12-18(25-19)20(21,22)23)15-9-6-10-16(11-15)27-13-14-7-4-3-5-8-14/h3-12H,2,13H2,1H3 | [InChIKey]
NTDFYGSSDDMNHI-UHFFFAOYSA-N | [SMILES]
CCS(=O)c1nc(cc(n1)C(F)(F)F)-c2cccc(OCc3ccccc3)c2 |
| Hazard Information | Back Directory | [Uses]
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoromethyl)pyrimidine acts as an allosteric modulator of the GLP-1 (glucagon-like peptide-1) receptor in preparation of orally therapeutic agents for the treatment of diabetes mellitus. | [Biological Activity]
BETP is a positive allosteric modulator of the GLP-1 receptor th at potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cellsin the presence of the weak GLP-1 metaboliteGLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).''BetP is a trimeric Na+-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K+-concentration. | [in vivo]
BETP has insulinotropic effect in SD rats. BETP (10 mg/kg, jugular vein cannula) exhibits insulin secretagogue activity in the intravenous glucose tolerance test (IVGTT) model. BETP (10 mg/kg, i.v.)-treated rats need 20% higher glucose infusion rates and demonstrates higher plasma insulin levels in SD rat hyperglycemic clamp model[1]. BETP (5 mg/kg) enhances oxyntomodulin-stimulated insulin secretion[2]. | [storage]
Store at +4°C |
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