| Identification | Back Directory | [Name]
Vitamin K1 cis-trans (1:1) D7 | [CAS]
1373049-34-3 | [Synonyms]
Vitamin K1 trans-D7
Phytonadione trans-d7
[2H7]-Trans-Phylloquinone
Vitamin K1 cis-trans (1:1) D7
Phytonadione cis-trans (1:1)-D7
[2H7]-Phytonadione(Vitamin K1) trans
[2H7]-Phytonadione(Vitamin K1) cis-trans (1:1) | [Molecular Formula]
C31H46O2 | [MOL File]
1373049-34-3.mol | [Molecular Weight]
450.71 |
| Chemical Properties | Back Directory | [form ]
Liquid
(Density: 0.999 g/cm3) | [color ]
Colorless to light yellow | [InChIKey]
MBWXNTAXLNYFJB-OJUGCUFGNA-N | [SMILES]
O=C1C(=C(C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C |&1:27,32,r| |
| Hazard Information | Back Directory | [Uses]
Vitamin K1-d7 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Basset GJ, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22. DOI:10.2174/1389557516666160623082714
[3] Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;2015:296721. DOI:10.1155/2015/296721
[4] Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8. DOI:10.3945/ajcn.111.033498
[5] Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. DOI:10.3164/jcbn.13-25
[6] Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46(4):409-12. DOI:10.4103/0253-7613.135953 |
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