| Identification | Back Directory | [Name]
1374107-46-6 | [CAS]
1374107-46-6 | [Synonyms]
1-[2-[4-(Dimethylamino)phenyl]quinolin-6-yl]oxy-3-fluoropropan-2-ol
2-Propanol, 1-[[2-[4-(dimethylamino)phenyl]-6-quinolinyl]oxy]-3-fluoro- | [Molecular Formula]
C20H21FN2O2 | [MDL Number]
MFCD29767867 | [MOL File]
1374107-46-6.mol | [Molecular Weight]
340.39 |
| Hazard Information | Back Directory | [Uses]
THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)? brain homogenates. 18F-THK-5105 has?the?potential to act as a tau imaging PET probe[1]. | [References]
[1] Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54(8):1420-7. DOI:10.2967/jnumed.112.117341 |
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