| Identification | Back Directory | [Name]
THK-5107 | [CAS]
1374107-54-6 | [Synonyms]
THK-5107
6-(3-Fluoro-2-hydroxypropoxy)-2-(4-methylaminophenyl)quinoline
1-fluoro-3-[2-[4-(methylamino)phenyl]quinolin-6-yl]oxypropan-2-ol
2-Propanol, 1-fluoro-3-[[2-[4-(methylamino)phenyl]-6-quinolinyl]oxy]- | [Molecular Formula]
C19H19FN2O2 | [MDL Number]
MFCD29767871 | [MOL File]
1374107-54-6.mol | [Molecular Weight]
326.36 |
| Chemical Properties | Back Directory | [Boiling point ]
548.8±50.0 °C(Predicted) | [density ]
1.246±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.84±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)? brain homogenates. 18F-THK-5117 has?the?potential to act as a tau imaging PET probe[1]. | [References]
[1] Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54(8):1420-7. DOI:10.2967/jnumed.112.117341 |
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