| Identification | Back Directory | [Name]
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | [CAS]
1374356-45-2 | [Synonyms]
(s)-g-fitinib
(S)-CRIZOTINIB
ent-crizotinib
Crizotinib, (S)-
Crizotinib S-Isomer
Crizotinib impurity A
Crizotinib Impurity 24
CRIZOTINIB CHIRAL IMPURITY
3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | [Molecular Formula]
C21H22Cl2FN5O | [MDL Number]
MFCD22126092 | [MOL File]
1374356-45-2.mol | [Molecular Weight]
450.34 |
| Chemical Properties | Back Directory | [Boiling point ]
599.2±50.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml | [form ]
A solid | [pka]
9.81±0.10(Predicted) | [color ]
Light yellow to yellow | [CAS DataBase Reference]
1374356-45-2 |
| Hazard Information | Back Directory | [Characteristics]
MTH1 (NUDT1)-selective inhibitor. | [Uses]
(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent. | [Definition]
ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib. | [Biological Activity]
(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM. | [target]
| Target | Value | MTH1
(Cell-free assay) | 72 nM |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|