| Identification | Back Directory | [Name]
DOTAGA-Anhydride | [CAS]
1375475-53-8 | [Synonyms]
DOTAGA-Anhydride
1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)-
2,2',2''-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid | [Molecular Formula]
C19H30N4O9 | [MDL Number]
MFCD33403099 | [MOL File]
1375475-53-8.mol | [Molecular Weight]
458.46 |
| Chemical Properties | Back Directory | [Boiling point ]
752.4±60.0 °C(Predicted) | [density ]
1.356±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.46±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C19H30N4O9/c24-15(25)11-20-3-5-21(12-16(26)27)7-9-23(14-1-2-18(30)32-19(14)31)10-8-22(6-4-20)13-17(28)29/h14H,1-13H2,(H,24,25)(H,26,27)(H,28,29) | [InChIKey]
BYBCIVKIWIFVFD-UHFFFAOYSA-N | [SMILES]
N1(CC(O)=O)CCN(C2CCC(=O)OC2=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 |
| Hazard Information | Back Directory | [Uses]
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies. | [IC 50]
RDC Bifunctional Chelator |
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| Company Name: |
Unibest Pharmaceutical Technology Co., Ltd.
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| Tel: |
13735578103 |
| Website: |
isite.baidu.com/site/wjzvpc43/3e462afc-f1d0-46aa-b5b6-46dbd294d89e?fid=nhf1pjcdpjcznhcvn1cyrhcdn1-xnwcdg1d&ch=4&bd_vid=nhf1pjcdpjcznhcvn1cyrhcdn1-xnwcdg17xnh0sg1wxp1b1pjr1pjczp1b&ch=4&bd_bxst= |
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