| Identification | Back Directory | [Name]
VT-464 (R enantioMer) | [CAS]
1375603-38-5 | [Synonyms]
VT-464 (R enantioMer)
Seviteronel R entiomer | [Molecular Formula]
C18H17F4N3O3 | [MDL Number]
MFCD28167779 | [MOL File]
1375603-38-5.mol | [Molecular Weight]
399.35 |
| Chemical Properties | Back Directory | [Boiling point ]
536.3±45.0 °C(Predicted) | [density ]
1.393±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (250.41 mM) | [form ]
Solid | [pka]
8.69±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Seviteronel R enantiomer (VT-464 R enantiomer) is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown. | [IC 50]
CYP17 | [storage]
Store at -20°C | [References]
[1] Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. DOI:10.1016/j.bmcl.2014.04.024
[2] Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models.
Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1 |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|