| Identification | Back Directory | [Name]
BISINDOLYLMALEIMIDE III | [CAS]
137592-43-9 | [Synonyms]
BISINDOLYLMALEIMIDE III
3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | [Molecular Formula]
C23H20N4O2 | [MDL Number]
MFCD01076633 | [MOL File]
137592-43-9.mol | [Molecular Weight]
384.43 |
| Chemical Properties | Back Directory | [Boiling point ]
708.7±60.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [solubility ]
DMSO: soluble; Methanol: soluble | [form ]
A crystalline solid | [pka]
8.15±0.60(Predicted) | [color ]
Brown to reddish brown |
| Hazard Information | Back Directory | [Description]
Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM. | [Uses]
Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway, | [Definition]
ChEBI: Bisindolylmaleimide III is a member of maleimides and a member of indoles. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide. | [IC 50]
PKCα | [References]
[1] PETER D. DAVIS. Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides[J]. Journal of Medicinal Chemistry, 1992, 35 1: 177-184. DOI: 10.1021/jm00079a024
[2] DAVID SORIANO-CASTELL Pamela M Antonio Currais. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis[J]. Free Radical Biology and Medicine, 2021, 171: Pages 219-231. DOI: 10.1016/j.freeradbiomed.2021.05.023 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|