| Identification | Back Directory | [Name]
Methanone, (3,4-dihydro-4-hydroxy-2(1H)-isoquinolinyl)[3-(3-hydroxy-3-methylbutyl)phenyl]- | [CAS]
1377897-01-2 | [Synonyms]
Methanone, (3,4-dihydro-4-hydroxy-2(1H)-isoquinolinyl)[3-(3-hydroxy-3-methylbutyl)phenyl]- | [Molecular Formula]
C21H25NO3 | [MOL File]
1377897-01-2.mol | [Molecular Weight]
339.43 |
| Chemical Properties | Back Directory | [Boiling point ]
569.4±50.0 °C(Predicted) | [density ]
1.206±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.62±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ERD03 is an inhibitor of RNA-binding by EXOSC3, disrupting the EXOSC3-RNA interaction in a concentration-dependent manner. | [Uses]
ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a?Kd?of 17±7?μM?. ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder?disease research[1]. | [References]
[1] Liberty Fran?ois-Moutal, et al. A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. DOI:10.1021/acschembio.8b00745 |
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