| Identification | Back Directory | [Name]
cis-4-Azido-N-Fmoc-D-proline | [CAS]
1378847-51-8 | [Synonyms]
Fmoc-(2R,4R)-4-azidoproline
(2R,4R)-Fmoc-D-Pro(4-N3)-OH
cis-4-Azido-N-Fmoc-D-proline | [Molecular Formula]
C20H18N4O4 | [MOL File]
1378847-51-8.mol | [Molecular Weight]
378.381 |
| Hazard Information | Back Directory | [Uses]
(2R,4R)-Fmoc-D-Pro(4-N3)-OH (cis-4-Azido-N-Fmoc-D-proline) is a click chemistry reagent containing an azide group[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [References]
[1] Rashad AA, et al. Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter. J Med Chem. 2015 Sep 24;58(18):7603-8. DOI:10.1021/acs.jmedchem.5b00935 |
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