| Identification | Back Directory | [Name]
Acetamide, 2-(aminooxy)-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | [CAS]
1379761-16-6 | [Synonyms]
Aminoxyacetamide-PEG3-azide
Acetamide, 2-(aminooxy)-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | [Molecular Formula]
C10H21N5O5 | [MDL Number]
MFCD31715363 | [MOL File]
1379761-16-6.mol | [Molecular Weight]
291.304 |
| Hazard Information | Back Directory | [Uses]
Aminoxyacetamide-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminoxyacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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