| Identification | Back Directory | [Name]
2H-Indol-2-one, 5-bromo-1,3-dihydro-7-methyl-3-(4-oxo-2-thioxo-5-thiazolidinylidene)-, (3Z)- | [CAS]
1380448-60-1 | [Synonyms]
2H-Indol-2-one, 5-bromo-1,3-dihydro-7-methyl-3-(4-oxo-2-thioxo-5-thiazolidinylidene)-, (3Z)- | [Molecular Formula]
C12H7BrN2O2S2 | [MOL File]
1380448-60-1.mol | [Molecular Weight]
355.23 |
| Hazard Information | Back Directory | [Description]
CFM-1 is an antagonist of anaphase-promoting complex (APC)-2 and cell cycle and apoptosis regulatory protein (CARP)-1 interaction. | [Uses]
CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells[1]. | [References]
[1] Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017. DOI:10.1074/jbc.M111.222398 |
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