| Identification | Back Directory | [Name]
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone | [CAS]
1380548-02-6 | [Synonyms]
SR10067
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl- | [Molecular Formula]
C31H31NO3 | [MDL Number]
MFCD31544491 | [MOL File]
1380548-02-6.mol | [Molecular Weight]
465.58 |
| Chemical Properties | Back Directory | [Boiling point ]
648.1±50.0 °C(Predicted) | [density ]
1.159±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-2.05±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SR 10067 is a novel Rev-erbα agonist. | [Biological Activity]
Cell permeable: yes''Primary Target
REV-ERB''Reversible: yes''Target IC50: 170 nM for REV-ERB&alpha | [in vivo]
SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse[1]. | Animal Model: | Mice[1] | | Dosage: | 30 mg/kg | | Administration: | i.p. | | Result: | Remained above the IC50 of the receptor in plasma and brain concentrations.
Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity.
Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.
|
| [storage]
Store at -20°C |
|
|