| Identification | Back Directory | [Name]
T2-aminoalcohol hydrochloride | [CAS]
1380782-27-3 | [Synonyms]
T2AA hydrochloride
T2-aminoalcohol hydrochloride
(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol hydrochloride | [Molecular Formula]
C15H16ClI2NO3 | [MDL Number]
MFCD30182241 | [MOL File]
1380782-27-3.mol | [Molecular Weight]
547.554 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1 | [InChIKey]
NKOSKXJRVWVXRI-JTQLQIEISA-N | [SMILES]
Ic1c(c(cc(c1)C[C@H](N)CO)I)Oc2ccc(cc2)O |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus. | [Uses]
T2AA is a small molecule inhibitor of PCNA/PIP-box interactions, which suppresses translesion DNA synthesis. | [Biochem/physiol Actions]
T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity. | [storage]
Store at -20°C |
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https://www.bocsci.com |
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cjbscvictory
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www.weikeqi-biotech.com/ |
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