| Identification | Back Directory | [Name]
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL | [CAS]
138090-06-9 | [Synonyms]
R)-THC
(R,R)-THC
(R,R)-CIS-DIETHYLTETRAHYDRO-2,8-CHRYSENEDIOL
5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
(R,R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
2,8-Chrysenediol, 5,11-diethyl-5,6,11,12-tetrahydro-, (5R,11R)-rel- | [Molecular Formula]
C22H24O2 | [MDL Number]
MFCD04039999 | [MOL File]
138090-06-9.mol | [Molecular Weight]
320.42 |
| Chemical Properties | Back Directory | [Melting point ]
>189°C (dec) | [Boiling point ]
519.0±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20 mg/mL | [form ]
solid | [pka]
10.27±0.60(Predicted) | [color ]
tan | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent and selective ligand that can be used to investigate the interactions between ligand and receptor of estrogen receptors (ERs) (1,2,3). cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is an ERα agonist and an ERβ antagonist. | [Uses]
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent ligands for the estrogen receptor. A series of tetrahydrochrysenes were prepared as fluorescent ligands for the estrogen receptor. | [Definition]
ChEBI:(R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. It has a role as an estrogen receptor antagonist, an estrogen receptor agonist, a geroprotector and a neuroprotective agent. It is a carbotetracyclic compound and a polyphenol. | [Biological Activity]
Non-steroidal, selective estrogen receptor ligand; agonist at ER α receptor (K i = 9.0 nM) and antagonist at ER β receptor (K i = 3.6 nM). | [storage]
Store at -20°C |
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