| Identification | Back Directory | [Name]
AIT 082 | [CAS]
138117-50-7 | [Synonyms]
AIT 082
Leteprinim
AIT 082 acid
NEOTROFIN; AIT-082
4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoic acid | [Molecular Formula]
C15H13N5O4 | [MDL Number]
MFCD00925649 | [MOL File]
138117-50-7.mol | [Molecular Weight]
327.29 |
| Hazard Information | Back Directory | [Uses]
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4]. | [Definition]
ChEBI: Leteprinim is an amidobenzoic acid. | [in vivo]
Leteprinim (30 or 60 mg/kg, i.p., for 7 days) protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4]. | Animal Model: | Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4] | | Dosage: | 60 mg/kg | | Administration: | IP; single dosage | | Result: | The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.
In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.
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| [References]
[1] Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. DOI:10.1006/exnr.2001.7654
[2] Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93. DOI:10.1111/j.1749-6632.2000.tb06390.x
[3] Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47(2):325-9. DOI:10.1016/0091-3057(94)90017-5
[4] Gencp?nar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10. DOI:10.1016/j.neulet.2011.10.027 |
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