| Identification | Back Directory | [Name]
1H-Imidazole-5-carboxylic acid, 2-[[[(4-fluorophenyl)methyl][[4-(phenylmethoxy)phenyl]methyl]amino]methyl]- | [CAS]
1382722-47-5 | [Synonyms]
MMPI-1154
1H-Imidazole-5-carboxylic acid, 2-[[[(4-fluorophenyl)methyl][[4-(phenylmethoxy)phenyl]methyl]amino]methyl]- | [Molecular Formula]
C26H24FN3O3 | [MDL Number]
MFCD32693883 | [MOL File]
1382722-47-5.mol | [Molecular Weight]
445.49 |
| Chemical Properties | Back Directory | [Boiling point ]
675.1±55.0 °C(Predicted) | [density ]
1.308±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.37±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively[1]. | [IC 50]
MMP-2: 6.6 μM (IC50); MMP-13: 1.8 μM (IC50); MMP-1: 10 μM (IC50); MMP-9: 13 μM (IC50) | [References]
[1] Péter Bencsik, et al. Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.Front Pharmacol. 2018 Apr 5;9:296. DOI:10.3389/fphar.2018.00296 |
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