| Identification | Back Directory | [Name]
MIK-8719 | [CAS]
1382799-40-7 | [Synonyms]
MK-8719
MIK-8719
5H-Pyrano[3,2-d]thiazole-6,7-diol, 5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-, (3aR,5S,6S,7R,7aR)- | [Molecular Formula]
C9H14F2N2O3S | [MDL Number]
MFCD32263431 | [MOL File]
1382799-40-7.mol | [Molecular Weight]
268.28 |
| Chemical Properties | Back Directory | [Boiling point ]
431.4±55.0 °C(Predicted) | [density ]
1.78±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (372.74 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.72±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1]. | [in vivo]
MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1]. | [storage]
Store at -20°C | [References]
[1] Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29. DOI:10.1021/acs.jmedchem.9b01090 |
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