| Identification | Back Directory | [Name]
1H-Indole, 5-bromo-2-[4-methoxy-5-(2H-pyrrol-2-ylidenemethyl)-1H-pyrrol-2-yl]- | [CAS]
1383727-17-0 | [Synonyms]
SC2001
SC-2001
SC 2001
1H-Indole, 5-bromo-2-[4-methoxy-5-(2H-pyrrol-2-ylidenemethyl)-1H-pyrrol-2-yl]- | [Molecular Formula]
C18H14BrN3O | [MOL File]
1383727-17-0.mol | [Molecular Weight]
368.23 |
| Hazard Information | Back Directory | [Description]
SC-2001 is a MCL-1 inhibitor. SC-2001 is an Obatoclax analog that inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. | [Uses]
SC-2001 is a compound structurally related to obatoclax that has better antitumor effects than obatoclax in liver cancer cell lines, downregulating Mcl-1 protein levels, inhibiting STAT3 phosphorylation, inducing apoptosis, and enhancing SHP1 expression and activity. | [References]
[1] A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation |
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