| Identification | Back Directory | [Name]
Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)- | [CAS]
1383982-64-6 | [Synonyms]
AZD3293
CS-2359
Lanabecestat
AZD3293 (LY3314814)
Lanabecestat (AZD3293)
Lanabecestat(AZD3293, LY3314814)
Lanabecestat ( LY3314814, AZD3293)
AZD 3293;LY3314814;AZD-3293;LY 3314814
(1r,1'R,4R)-4-methoxy-5''-methyl-6'-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3'H-dispiro[cyclohexane-1,2'-inden-1',2'-imidazole]-4''-amine
Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C26H28N4O | [MOL File]
1383982-64-6.mol | [Molecular Weight]
412.53 |
| Chemical Properties | Back Directory | [Boiling point ]
621.9±65.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A solid | [pka]
4.60±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Lanabecestat (AZD3293) is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. Lanabecestat is used for the research of Alzheimer's disease[1]. | [in vivo]
In mice, guinea pigs, and dogs, lanabecestat displays significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ[1]. | [IC 50]
BACE1 | [storage]
Store at -20°C | [References]
[1] Eketj?ll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50(4):1109-23. DOI:10.3233/JAD-150834 |
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