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1384263-83-5

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1384263-83-5 Structure

1384263-83-5 Structure
IdentificationBack Directory
[Name]

Fmoc-Ala-Ala-PAB
[CAS]

1384263-83-5
[Synonyms]

Fmoc-Ala-Ala-PAB
[Molecular Formula]

C28H29N3O5
[MOL File]

1384263-83-5.mol
[Molecular Weight]

487.56
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319
[Precautionary statements ]

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard InformationBack Directory
[Uses]

Fmoc-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Cleavable Linker
[References]

[1] Wayne C Widdison, et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. Bioconjug Chem. 2015 Nov 18;26(11):2261-78. DOI:10.1021/acs.bioconjchem.5b00430
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