| Identification | Back Directory | [Name]
SYP-5 | [CAS]
1384268-04-5 | [Synonyms]
SYP-5
SYP5; SYP 5
SYP-5 >=98% (HPLC)
2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)- | [Molecular Formula]
C18H16O3S | [MDL Number]
MFCD30534394 | [MOL File]
1384268-04-5.mol | [Molecular Weight]
312.38 |
| Chemical Properties | Back Directory | [Boiling point ]
502.0±50.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM) | [form ]
A solid | [pka]
7.12±0.40(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. | [Biological Activity]
SYP-5, an inhibitor of Hypoxia-inducible factor-1 (HIF-1), inhibits tumor cell migration and invasion and tumor angiogenesis. | [in vitro]
SYP-5 inhibits hypoxia-induced upregulation of HIF-1. It inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. It inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down -regulated by SYP-5. | [target]
| [storage]
Store at -20°C | [References]
[1] Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568. DOI:10.1016/j.ejphar.2016.09.027 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|