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GPR119 agonist 2 (compound 43) is an orally active GPR119 agonist. GPR119 agonist 2 shows good pharmacokinetic characteristics in rodents and can effectively improve glucose tolerance in mice and rats. GPR119 agonist 2 has the potential to study type 2 diabetes[1]. | [References]
[1] Kim H, et al. Discovery of orally active sulfonylphenyl thieno [3, 2-d] pyrimidine derivatives as GPR119 agonists. Eur J Med Chem. 2023: 115584. |
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