| Identification | Back Directory | [Name]
Diphlorethohydroxycarmalol | [CAS]
138529-04-1 | [Synonyms]
Diphlorethohydroxycarmalol
Diphlorethohydroxycarmalol （DPHC）
Dibenzo[b,e][1,4]dioxin-1,2,6,8-tetrol, 7-(3,5-dihydroxyphenoxy)-3-(2,4,6-trihydroxyphenoxy)- | [Molecular Formula]
C24H16O13 | [MOL File]
138529-04-1.mol | [Molecular Weight]
512.38 |
| Chemical Properties | Back Directory | [Boiling point ]
784.9±60.0 °C(Predicted) | [density ]
1.861±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.89±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities[1]. | [in vivo]
The increase of postprandial blood glucose levels are significantly suppressed in the Diphlorethohydroxycarmalol-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) is significantly reduced via Diphlorethohydroxycarmalol (100 mg/kg; p.o.) administration (2022 versus 2210 mmol x min/lL) in the diabetic mice as well as it delays absorption of dietary carbohydrates[1]. | [References]
[1] Soo-Jin Heo, et al. Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol. 2009 Aug 1;615(1-3):252-6. DOI:10.1016/j.ejphar.2009.05.017 |
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