| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
Off-white to light yellow | [Sequence]
RNA, (A-U-G-G-A-A-Um-A-C-U-C-U-U-G-G-U-Um-A-C-dT-dT), complex with RNA (G-Um-A-ACm-Cm-A-A-G-A-G-Um-A-Um-Um-Cm-Cm-A-Um-dT-dT) (1:1) sodium salt |
| Hazard Information | Back Directory | [Uses]
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis[1][2][3]. | [References]
[1] Adams D, et, al. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018 Jul 5;379(1):11-21. DOI:10.1056/NEJMoa1716153
[2] Hoy SM. Patisiran: First Global Approval. Drugs. 2018 Oct;78(15):1625-1631. DOI:10.1007/s40265-018-0983-6
[3] Kristen AV, et, al. Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin-mediated amyloidosis. Neurodegener Dis Manag. 2019 Feb;9(1):5-23. DOI:10.2217/nmt-2018-0033 |
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Apextide Co Ltd Gold
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| Tel: |
15300650552; 15300650552 |
| Website: |
http://www.apextide.com |
| Company Name: |
Ribobay Gold
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(86) 0550-5361572 13958538646 |
| Website: |
www.ribobay.com/en/ |
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