| Identification | Back Directory | [Name]
KPT 251, >=98% | [CAS]
1388841-50-6 | [Synonyms]
KPT251
AOB6639
KPT 251, >=98%
SCHEMBL11318201
SCHEMBL11318201; AOB6639;
2-[(Z)-2-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}vinyl]-1,3,4-oxadiazole | [Molecular Formula]
C14H7F6N5O | [MDL Number]
MFCD28144513 | [MOL File]
1388841-50-6.mol | [Molecular Weight]
375.23 |
| Chemical Properties | Back Directory | [Boiling point ]
417.9±55.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 25mg/mL | [form ]
Solid | [pka]
-0.42±0.50(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
KPT 251 is a novel CRM1 inhibitor, which has been shown to be effective in the treatment of acute myeloid leukemia. | [Biological Activity]
Cell permeable: yes''Primary Target
XPO1''Reversible: no | [in vivo]
KPT-251 (75 mg/kg/day; i.g.; three times per week for 5 weeks) effectively suppresses the growth of MV4-11 cells engrafted into NSG mice and provides a significant survival benefit[1].
KPT-251 (50 mg/kg; p.o.; every other day for 21 days) suppresses tumor growth in mice melanoma xenograft models[2]. | Animal Model: | 7-weekold female NOD-SCID-IL2Rcγnull (NSG) mice, introduced 2 × 106 luciferase-expressing MV4-11 cells via tail-vein injections[1] | | Dosage: | 75 mg/kg/day | | Administration: | Gavage, three times per week for 5 weeks | | Result: | Exhibited significantly increased survival with leukemia progression occurring only after cessation of treatment, prevented infiltration of leukemia cells into mouse bone marrow and spleen, and spared normal hematopoietic cells. |
| Animal Model: | Athymic nude mice Nu/Nu, melanoma xenograft models[2] | | Dosage: | 50 mg/kg | | Administration: | Oral, every other day for 21 days | | Result: | Suppressed tumor growth, increased cleaved caspase-3 and decreased Ki67. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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