| Identification | Back Directory | [Name]
2-Cyclopentene-1-carboxylicacid,4-amino-,methylester,(1S,4R)-(9CI) | [CAS]
138923-03-2 | [Synonyms]
(1S,4R)-Methyl 4-aMinocyclopent-2-enecarboxylate
Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate
methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate
(1S,4R)-2-CYCLOPENTENE-1-CARBOXYLIC ACID, 4-AMINOMETHYL ESTER
(1S,4R)-Methyl 4-aMinocyclopent-2-enecarboxylate L-tartrate salt
Cis-(1S,4R)-4-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
2-Cyclopentene-1-carboxylicacid,4-amino-,methylester,(1S,4R)-(9CI)
2-Cyclopentene-1-carboxylic acid, 4-amino-, methyl ester, (1S,4R)- | [Molecular Formula]
C7H11NO2 | [MDL Number]
MFCD16293378 | [MOL File]
138923-03-2.mol | [Molecular Weight]
141.17 |
| Chemical Properties | Back Directory | [Boiling point ]
191.9±40.0 °C(Predicted) | [density ]
1.109±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
9.66±0.40(Predicted) | [InChI]
InChI=1S/C7H11NO2/c1-10-7(9)5-2-3-6(8)4-5/h2-3,5-6H,4,8H2,1H3/t5-,6+/m1/s1 | [InChIKey]
ANVYHALMQXHQSG-RITPCOANSA-N | [SMILES]
[C@H]1(C(OC)=O)C[C@@H](N)C=C1 |
| Hazard Information | Back Directory | [Uses]
Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
Weigh 50g of the by-product (+)1-amino-4-carboxy-2-cyclopentene extracted by γ-lactam enzymatic resolution and put it in a flask, add 200g of water, and slowly add dropwise at 25~30℃ Sulfuric acid, adjust the pH value of the solution to 1~2, after the dripping is completed, add 0.1g of the racemic catalyst o-phthalaldehyde, then heat to reflux, and react for 10~15h. Concentrate under reduced pressure to no fraction, add 200ml of methanol, 20g of tartaric acid, cool to 10-20°C, filter and wash with methanol. Then add 20g of thionyl chloride and 100ml of methanol to the filter cake, react at 65°C for 8h and concentrate under reduced pressure until there is no fraction. Add 100ml of dichloromethane, stir to dissolve and wash the dichloromethane layer twice with drinking water to obtain (- ) Methyl 1-amino-4-carboxylate-2-cyclopentene in dichloromethane solution, yield 42%.
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| Company Name: |
Acesys Pharmatech
|
| Telephone: |
18860950986 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15849/0_EN.htm |
| Company Name: |
Shanghai UCHEM Inc.
|
| Telephone: |
+86-18930848214 +86-021-56762820 |
| Website: |
http://www.myuchem.com/ |
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