| Identification | Back Directory | [Name]
benastatin B | [CAS]
138968-86-2 | [Synonyms]
benastatin B
Benzo[a]naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-13,13-dimethyl-8-oxo-3-pentyl- | [Molecular Formula]
C30H30O7 | [MOL File]
138968-86-2.mol | [Molecular Weight]
502.55 |
| Chemical Properties | Back Directory | [Boiling point ]
759.3±60.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
A powder | [pka]
2.99±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC50 of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC50 of 79 μg/mL[1][2]. | [References]
[1] Aoyama T, et al., Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B. J Antibiot (Tokyo). 1992 Sep;45(9):1391-6. DOI:10.7164/antibiotics.45.1391
[2] Tsakem B, et al., Structures, biosynthesis and biological activities of benastatins, anthrabenzoxocinones and fredericamycins. Bioorg Chem. 2024 Sep;150:107572. DOI:10.1016/j.bioorg.2024.107572 |
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