| Identification | Back Directory | [Name]
RP 72540 | [CAS]
139088-45-2 | [Synonyms]
RP 72540
RPR102681
RPR-102681
RPR 102681
(+)-RP 72540
RP 72540,RP72540
Glycinamide, N-[[[3-(1-carboxyethyl)phenyl]amino]carbonyl]glycyl-N2-(3-methoxyphenyl)-N-methyl-N-phenyl- | [Molecular Formula]
C28H30N4O6 | [MOL File]
139088-45-2.mol | [Molecular Weight]
518.561 |
| Hazard Information | Back Directory | [Uses]
RP 72540 is a selective CCK-B receptor antagonist, with IC50 values of 2.4, 1.2, and 3.8 nM for CCK-B receptors in the guinea pig cerebral cortex, rat cerebral cortex, and mouse brain, respectively. RP 72540 effectively inhibits CCK-8-induced neuronal firing and dose-dependently inhibits gastric acid secretion, making it potentially valuable in studies of acid secretion. RP 72540 is an important tool for investigating the physiological functions of CCK B receptors[1]. | [References]
[1] Bertrand P, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45. DOI:10.1016/0014-2999(94)90737-4 |
|
|