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1391063-17-4

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1391063-17-4 Structure

1391063-17-4 Structure
IdentificationBack Directory
[Name]

Bosutinib Impurity 5
[CAS]

1391063-17-4
[Synonyms]

Bosutinib isomer 1
Bosutinib Isomer I
Bosutinib Isomer I (PF-06651481-00)
3-Quinolinecarbonitrile, 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-
[Molecular Formula]

C26H29Cl2N5O3
[MDL Number]

MFCD22418831
[MOL File]

1391063-17-4.mol
[Molecular Weight]

530.45
Chemical PropertiesBack Directory
[storage temp. ]

room temp
[solubility ]

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
[form ]

Solid
[color ]

White to Light Brown
[Stability:]

Stable under recommended storage conditions., Stable Under Recommended Storage C
Hazard InformationBack Directory
[Uses]

Kinase inhibitors, such as?bosutinib,?are useful cancer drugs but their target specificity is not fully understood. 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile has been employed as a clinical kinase inhibitor bosutinib to elucidate the recognition mechanism between the ATP-binding site and the compound.
[Biological Activity]

PF-06651481-00 is an isomer of orally available dual Src/Abl kinase inhibitor Bosutinib.
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