| Identification | Back Directory | [Name]
BM-1074 | [CAS]
1391108-10-3 | [Synonyms]
BM-1074
1H-Pyrrole-3-carboxamide, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-N-(methylsulfonyl)- | [Molecular Formula]
C50H57ClN8O7S3 | [MDL Number]
MFCD26960894 | [MOL File]
1391108-10-3.mol | [Molecular Weight]
1013.68 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO mg/mL Water mg/mL Ethanol mg/mL | [pka]
2.32±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete, and durable tumor regression in vivo. | [in vivo]
BM-1074 (i.v., 15 mg/kg, daily, 5 days a week for 2 weeks) exhibits the maximum tolerated dose (MTD) (15 mg/kg) and strong antitumor activity in H146 tumor xenograft mice, as well as shows no significant weight loss (<5%) or other signs of toxicity[1].
BM-1074 (i.v., 15 mg/kg, single) induces strong apoptosis in H146 tumor tissues[1].
| Animal Model: | SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1] | | Dosage: | 15 mg/kg | | Administration: | i.v., 15 mg/kg, daily, 5 days a week for 2 weeks | | Result: | Showed good toleration and did not cause significant weight loss or other signs of toxicity, also induced completely and persistent tumor regression in the H146 xenograft model. |
| Animal Model: | SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1] | | Dosage: | 15 mg/kg | | Administration: | i.v., 15 mg/kg, single dosage | | Result: | Induced robust cleavage of PARP and caspase-3 at both 3 and 6-hr time-points in H146 tumor tissues. |
| [IC 50]
Bcl-2: 1.8 nM (IC50); Bcl-xL: 6.9 nM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|