| Identification | Back Directory | [Name]
2-Amino-7-(chloromethyl)pteridin-4(1H)-one | [CAS]
1391194-56-1 | [Synonyms]
Folic Acid Impurity 4
2-Amino-7-(chloromethyl)pteridin-4(1H)-one
4(3H)-Pteridinone, 2-amino-7-(chloromethyl)-
Folic Acid Impurity 4（Folic Acid EP Impurity F）
2-Amino-7-(chloromethyl)pteridin-4(1H)-one (90%) | [Molecular Formula]
C7H6ClN5O | [MOL File]
1391194-56-1.mol | [Molecular Weight]
211.61 |
| Chemical Properties | Back Directory | [Melting point ]
>292°C (dec.) | [Boiling point ]
370.0±44.0 °C(Predicted) | [density ]
1.91±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [pka]
1.79±0.20(Predicted) | [color ]
Dark Yellow | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C7H6ClN5O/c8-1-3-2-10-4-5(11-3)12-7(9)13-6(4)14/h2H,1H2,(H3,9,11,12,13,14) | [InChIKey]
WHPPYWZHBUBHST-UHFFFAOYSA-N | [SMILES]
N1C2C(=NC=C(CCl)N=2)C(=O)NC=1N |
| Hazard Information | Back Directory | [Uses]
2-Amino-7-(chloromethyl)pteridin-4(1H)-one is the impurity F of Folic acid (F680300) as per EP monograph. | [Synthesis]
2-Amino-7-(chloromethyl)pteridin-4(1H)-one can be prepared by a condensation reaction between 2,4,5,6-tetraaminopyrimidine sulfate and 1,1,3 trichloroacetone in the presence of an antioxidant. |
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TOSUN PHARM
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www.toref.cn/ |
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