| Identification | Back Directory | [Name]
ISOVALERYL-L-CARNITINE CHLORIDE | [CAS]
139144-12-0 | [Synonyms]
ISOVALERYL-L-CARNITINE CHLORIDE
L-CARNITINE:HCL, O-ISOVALERYL UNLABELED
Isovaleryl-L-carnitine-d3 HCl (N-methyl-d3) | [Molecular Formula]
C12H22ClNO3 | [MDL Number]
MFCD09263554 | [MOL File]
139144-12-0.mol | [Molecular Weight]
263.761 |
| Chemical Properties | Back Directory | [Melting point ]
>160°C (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Methanol (Slightly), Water (Slightly, Heated) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic | [CAS Number Unlabeled]
139144-12-0 |
| Hazard Information | Back Directory | [Description]
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia). | [Uses]
Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ROBERTO PAOLO REVOLTELLA . l-Carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation[J]. Biochimica et biophysica acta. Molecular cell research, 1994, 1224 3: Pages 333-341. DOI: 10.1016/0167-4889(94)90265-8
[3] G MIOTTO. Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane.[J]. The Journal of Biological Chemistry, 1992, 267 31: 22066-22072.
[4] PIERO RINALDO Dietrich M Tina M Cowan. Acylcarnitine profile analysis[J]. Genetics in Medicine, 2008, 10 2: Pages 151-156. DOI: 10.1097/gim.0b013e3181614289 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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