139144-12-0

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139144-12-0 Structure

Identification	Back Directory
[Name] ISOVALERYL-L-CARNITINE CHLORIDE
[CAS] 139144-12-0
[Synonyms] ISOVALERYL-L-CARNITINE CHLORIDE L-CARNITINE:HCL, O-ISOVALERYL UNLABELED Isovaleryl-L-carnitine-d3 HCl (N-methyl-d3)
[Molecular Formula] C12H22ClNO3
[MDL Number] MFCD09263554
[MOL File] 139144-12-0.mol
[Molecular Weight] 263.761

Chemical Properties	Back Directory
[Melting point ] >160°C (dec.)
[storage temp. ] Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ] Methanol (Slightly), Water (Slightly, Heated)
[form ] Solid
[color ] White to Off-White
[Stability:] Hygroscopic

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H319-H317
[Precautionary statements ] P261-P264-P272-P280-P302+P352-P305+P351+P338-P333+P313-P321-P337+P313-P363-P501

Hazard Information	Back Directory
[Description] Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).
[Uses] Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
[IC 50] Human Endogenous Metabolite
[storage] Store at -20°C

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