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Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease[1]. | [in vivo]
Landogrozumab (3 and 15 mg/kg; i.v. once) affects muscle mass of aged mice with duchenne muscular dystrophy[1]. | Animal Model: | Duchenne muscular dystrophy (DMD) C57BL/10-mdx mouse model[1] | | Dosage: | 3 and 50 mg/kg | | Administration: | Intravenous injection; 3 and 50 mg/kg once | | Result: | Increasesd muscle mass of aged mice at a dose of 50 mg/kg while 3 mg/kg showed no significant effects.
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| [References]
[1] Muramatsu H, et al. Novel myostatin-specific antibody enhances muscle strength in muscle disease models. Sci Rep. 2021 Jan 25;11(1):2160. DOI:10.1038/s41598-021-81669-8 |
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