| Identification | Back Directory | [Name]
BMS-955176 | [CAS]
1392312-45-6 | [Synonyms]
GSK3532795
BMS-955176
BMS-955176(free base)
GSK-3532795,GSK3532795
BMS-955176
(GSK-3532795
Benzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]- | [Molecular Formula]
C42H62N2O4S | [MDL Number]
MFCD32062754 | [MOL File]
1392312-45-6.mol | [Molecular Weight]
691.02 |
| Chemical Properties | Back Directory | [Boiling point ]
780.7±60.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [solubility ]
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | [form ]
Solid | [pka]
4.36±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GSK3532795 (BMS-955176) is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC50s of 1.9, 10.2, 2.7 and 13 nM for HIV-1 WT, HIV-1 WT(human serum), HIV-1 V370A, and HIV-1 ΔV370, respectively[1]. | [IC 50]
HIV-1 | [References]
[1] Regueiro-Ren A, et al. Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176). J Med Chem. 2018 Aug 23;61(16):7289-7313. DOI:10.1021/acs.jmedchem.8b00854 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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