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1392502-55-4

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1392502-55-4 Structure

1392502-55-4 Structure

Identification	Back Directory
[Name] Benzoic acid, 2-hydroxy-, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxophenanthro[1,2-b]furan-9-yl ester
[CAS] 1392502-55-4
[Synonyms] Benzoic acid, 2-hydroxy-, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxophenanthro[1,2-b]furan-9-yl ester
[Molecular Formula] C26H22O6
[MOL File] 1392502-55-4.mol
[Molecular Weight] 430.45

Chemical Properties	Back Directory
[Boiling point ] 610.8±55.0 °C(predicted)
[density ] 1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 7.98±0.30(predicted)

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[Uses] NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC50 is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis[1].
[References] [1] Chen H, et al., Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 May 15;104:129725. DOI:10.1016/j.bmcl.2024.129725

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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