| Identification | Back Directory | [Name]
Benzoic acid, 2-hydroxy-, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxophenanthro[1,2-b]furan-9-yl ester | [CAS]
1392502-55-4 | [Synonyms]
Benzoic acid, 2-hydroxy-, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxophenanthro[1,2-b]furan-9-yl ester | [Molecular Formula]
C26H22O6 | [MOL File]
1392502-55-4.mol | [Molecular Weight]
430.45 |
| Hazard Information | Back Directory | [Uses]
NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC50 is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis[1]. | [References]
[1] Chen H, et al., Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 May 15;104:129725. DOI:10.1016/j.bmcl.2024.129725 |
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