| Identification | Back Directory | [Name]
2-AMino-4-chloro-pyriMidine-5-carbonitrile | [CAS]
1393179-35-5 | [Synonyms]
EOS-60723
2-Amino-4-chloro-5-cyanopyrimidine
2-Amino-4-chloro-5-pyrimidinecarbonitrile
2-AMino-4-chloro-pyriMidine-5-carbonitrile
5-Pyrimidinecarbonitrile, 2-amino-4-chloro- | [Molecular Formula]
C5H3ClN4 | [MDL Number]
MFCD27923125 | [MOL File]
1393179-35-5.mol | [Molecular Weight]
154.56 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-4-chloro-5-cyanopyrimidine from 2,4-dichloropyrimidine-5-carbonitrile: To a solution of 2,4-dichloropyrimidine-5-carbonitrile (600 mg, 3.45 mmol) in dioxane (20 mL) was added a dioxane solution of 0.5 M ammonia (20 mL, 10 mmol). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, two isomers were isolated by column chromatography using a hexane/ethyl acetate solvent mixture (ethyl acetate ratio increased from 0% to 45%). Among them, 2-amino-4-chloro-5-cyanopyrimidine (304 mg, 56% yield) was isolated as the less polar isomer. Low resolution mass spectrometry (LRMS) showed m/z of 153 (M-1). | [References]
[1] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 166 |
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