| Hazard Information | Back Directory | [Uses]
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2]. | [Definition]
ChEBI: 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine is a benzodiazepine. | [in vivo]
Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2]. | Animal Model: | C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2] | | Dosage: | 17.5 mg/kg, 35 mg/kg, and 70 mg/kg | | Administration: | i.p.; daily; for 14 or 21 days | | Result: | Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model. |
| [IC 50]
HIV-1 | [References]
[1] A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. DOI:10.1006/cimm.1996.0088
[2] Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. DOI:10.1016/j.ajpath.2021.04.006 |
|
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|