| Identification | Back Directory | [Name]
Bio-AMS | [CAS]
1393881-52-1 | [Synonyms]
Bio-AMS
Adenosine, 5'-deoxy-5'-[[[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]sulfonyl]amino]- | [Molecular Formula]
C20H29N9O7S2 | [MOL File]
1393881-52-1.mol | [Molecular Weight]
571.63 |
| Hazard Information | Back Directory | [Uses]
Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis[1][2]. | [References]
[1] Bockman MR, Aldrich CC, et al. Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification. ACS Infect Dis. 2018 Jul 13;4(7):1102-1113. DOI:10.1021/acsinfecdis.8b00038
[2] Tiwari D, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Sci Transl Med. 2018 Apr 25;10(438):eaal1803. DOI:10.1126/scitranslmed.aal1803 |
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