| Identification | Back Directory | [Name]
millepachine | [CAS]
1393922-01-4 | [Synonyms]
millepachine
(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)-prop-2-en-1-one
2-Propen-1-one, 1-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-(4-methoxyphenyl)-, (2E)-
Chinese,Millepachine,Millettia,bioactive,chalcone,medicine,natural,Inhibitor,pachycarpa,inhibit,antitumor,herbal,Benth,Apoptosis,cancer | [Molecular Formula]
C22H22O4 | [MOL File]
1393922-01-4.mol | [Molecular Weight]
350.41 |
| Chemical Properties | Back Directory | [Boiling point ]
528.2±50.0 °C(Predicted) | [density ]
1.139±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo[1]. | [in vivo]
Millepachine (20 mg/kg; i.v. every two days for 14 day) inhibits tumor growth in mice[1].
Millepachine (20 mg/kg; i.v. every two days for 14 day) does not induce acquired drug resistance in an excised A2780S xenograft model[1]. | Animal Model: | Female BALB/c nude mice (6 weeks) are injected A2780S or A2780CP cells[1] | | Dosage: | 20 mg/kg | | Administration: | I.v. every two days for 2-14 days | | Result: | Reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S (after seven times injection) and A2780CP (after six times injection) xenograft model, respectively.
With low toxicity in vivo.
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| [References]
[1] Wu W, et, al. Millepachine showed novel antitumor effects in cisplatin-resistant human ovarian cancer through inhibiting drug efflux function of ATP-binding cassette transporters. Phytother Res. 2018 Dec; 32(12):2428-2435. DOI:10.1002/ptr.6180 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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