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139570-93-7

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139570-93-7 Structure

139570-93-7 Structure
IdentificationBack Directory
[Name]

AN152
[CAS]

139570-93-7
[Synonyms]

AN152
AEZS 108
Batifiban
ZOPTARELIN DOXORUBICIN
OOUACICUAVTCEC-LZHWUUGESA-N
AEZS 108; AEZS108; ZOPTARELIN DOXORUBICIN; AN 152; AN-152; AN152
Luteinizing hormone-releasing factor (swine), 6-[N6-[5-[2-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-oxoethoxy]-1,5-dioxopentyl]-D-lysine]-
[Molecular Formula]

C91H117N19O26
[MDL Number]

MFCD25977754
[MOL File]

139570-93-7.mol
[Molecular Weight]

1893.01
Chemical PropertiesBack Directory
[density ]

1.57±0.1 g/cm3(Predicted)
[pka]

7.34±0.60(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)
GHS08
[Signal word ]

Danger
[Hazard statements ]

H350-H360-H340
Hazard InformationBack Directory
[Uses]

Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].
[in vivo]

Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice[1].

Animal Model:Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)[1]
Dosage:413 nM/20g
Administration:i.v.; once weekly; for 6 weeks
Result:Significantly inhibited tumor growth compared to the control.
[References]

[1] Jaszberenyi M, et al. Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone. Oncotarget. 2013 Mar;4(3):422-32. DOI:10.18632/oncotarget.917
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