| Identification | Back Directory | [Name]
N'-AMINOOXYMETHYLCARBONYLHYDRAZINO-D-BIOTIN | [CAS]
139585-03-8 | [Synonyms]
Arp(AldehydeReactiveProbe)
N-(Aminooxyacetyl)-N'-biotinyl-hydrazine
O-(biotinylcarbazoylmethyl)hydroxylamine
N'-AMINOOXYMETHYLCARBONYLHYDRAZINO-D-BIOTIN
N'-Aminooxymethylcarbonylhydrazino-D-biotin (ARP)
1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2-[2-(aminooxy)acetyl]hydrazide, (3aS,4S,6aR)- | [Molecular Formula]
C12H21N5O4S | [MDL Number]
MFCD01631933 | [MOL File]
139585-03-8.mol | [Molecular Weight]
331.39 |
| Hazard Information | Back Directory | [Uses]
ARP (Aldehyde reactive probe) is an aldehyde reactive probe for detecting abasic site (common DNA lesions and intermediates in mutagenesis and carcinogenesis) in DNA, which specificially tags AP site with biotin residues. ARP is highly sensitive with a femtomolar-level basic site detection capabilities (less than one site per 104 nucleotides)[1]. | [References]
[1] Kubo K, et al., A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion. Biochemistry. 1992 Apr 14;31(14):3703-8. DOI:10.1021/bi00129a020 |
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