| Identification | Back Directory | [Name]
Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- | [CAS]
1396814-79-1 | [Synonyms]
VU0542270
VU 0542270 New
Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-
1-((4-Methyl-2-(thiophen-2-yl)thiazol-5-yl)methyl)-3-(thiophen-2-yl)urea | [Molecular Formula]
C14H13N3OS3 | [MOL File]
1396814-79-1.mol | [Molecular Weight]
335.47 |
| Chemical Properties | Back Directory | [density ]
1.425±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml | [pka]
12.55±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
VU0542270 is an inhibitor of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.1 (SUR2B/Kir6.1; IC50 = 0.11 µM).1 It is selective for SUR2B/Kir6.1 over ten other inward-rectifier potassium channels (Kirs; IC50s = >30 µM for all). VU0542270 (10 or 100 µM) induces constriction in isolated mouse ductus arteriosus vessels.WARNING This product is not for human or veterinary use. | [References]
[1] LI K, MCCLENAHAN S J, HAN C, et al. Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B KATPchannels[J]. Molecular Pharmacology, 2024, 14 1. DOI: 10.1124/molpharm.123.000783 |
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