| Identification | Back Directory | [Name]
Avadomide hydrochloride | [CAS]
1398053-45-6 | [Synonyms]
CC 122 HCl
Avadomide HCl
CC122, Avadomide HCl
Avadomide hydrochloride | [Molecular Formula]
C14H15ClN4O3 | [MOL File]
1398053-45-6.mol | [Molecular Weight]
322.75 |
| Hazard Information | Back Directory | [Uses]
Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities[1][2][3]. | [References]
[1] Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98. DOI:10.1158/1078-0432.CCR-18-1203
[2] Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89. DOI:10.1182/blood-2015-02-628669
[3] Nishi H, et al., Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. DOI:10.1007/s00280-023-04531-w |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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