| Identification | Back Directory | [Name]
palbinone | [CAS]
139954-00-0 | [Synonyms]
palbinone
18-Norandrosta-11,13(17)-diene-15,16-dione, 3,17-dihydroxy-4,4,8,14-tetramethyl-, (3β,5α)-
(3beta,5alpha)-3,17-Dihydroxy-4,4,8,14-tetramethyl-18-norandrosta-11,13(17)-diene-15,16-dione | [Molecular Formula]
C22H30O4 | [MDL Number]
MFCD26406094 | [MOL File]
139954-00-0.mol | [Molecular Weight]
358.47 |
| Chemical Properties | Back Directory | [Boiling point ]
508.5±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6.72±0.70(Predicted) | [color ]
Orange |
| Hazard Information | Back Directory | [Uses]
Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits 3α-hydroxysteroid dehydrogenase (3α-HSD), with an IC50 of 46 nM. Anti-inflammatory activity[1]. | [Definition]
ChEBI: A natural product found in Paeonia rockii subspecies rockii. | [target]
HO-1 | Nrf2 | PI3K | Akt | ERK | NADPH-oxidase | [References]
[1] Kadota S, et al. Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase. Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90. DOI:10.1248/cpb.41.487 |
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