| Identification | Back Directory | [Name]
2-methoxy-4,6-dimethylpyrimidine | [CAS]
14001-61-7 | [Synonyms]
2-methoxy-4,6-dimethylpyrimidine
Pyrimidine, 2-methoxy-4,6-dimethyl-
Pyrimidine, 2-methoxy-4,6-dimethyl- (6CI,8CI,9CI)
2-methoxy-4,6-dimethylpyrimidine ISO 9001：2015 REACH | [Molecular Formula]
C7H10N2O | [MDL Number]
MFCD02765642 | [MOL File]
14001-61-7.mol | [Molecular Weight]
138.17 |
| Hazard Information | Back Directory | [Synthesis]
1. acetylacetone (50.0 g, 0.5 mol) and potassium carbonate (K2CO3, 138.0 g, 1.0 mol) were dissolved in water (250 mL).
2. O-methylisourea sulfate (61.5 g, 0.25 mol) was added to the above solution and the reaction mixture was refluxed with stirring.
3. After completion of the reaction, it was cooled to room temperature, potassium carbonate (70 g) was added and the reaction mixture was allowed to stand at 25 °C for 48 hours.
4. The oily product formed was separated, combined with ether and extracted with aqueous phase, followed by drying the organic layer with magnesium sulfate (MgSO4).
5. The dried organic layer was concentrated under vacuum.
6. The product was purified by vacuum distillation to give 2-methoxy-4,6-dimethylpyrimidine (48.3 g, 70% yield) as a yellow oil.
7. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.65 (s, 1H), 3.97 (s, 3H), 2.40 (s, 6H). | [References]
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 16, p. 4921 - 4935 |
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