| Identification | Back Directory | [Name]
4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE | [CAS]
14001-63-9 | [Synonyms]
SPECS AR-527/42979548
2-Methylthio-4-MethylpyriMidine
4-Methyl-2-Thiomethyl Pyrimidine
4-METHYL-2-(METHYLTHIO)PYRIMIDINE
4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE
Pyrimidine, 4-methyl-2-(methylthio)-
4-Methyl-2-(Methylthio)pyriMidine 97%
4-Methyl-2-(methylsulphanyl)pyrimidine
4-Methyl-2-(methylthio)pyrimidine ,97%
Pyrimidine, 4-methyl-2-(methylthio)- (6CI, 8CI, 9CI) | [Molecular Formula]
C6H8N2S | [MDL Number]
MFCD00023242 | [MOL File]
14001-63-9.mol | [Molecular Weight]
140.21 |
| Chemical Properties | Back Directory | [Boiling point ]
78-80°/1mm | [density ]
1.007 g/mL at 25 °C
| [refractive index ]
n20/D 1.572
| [Fp ]
220 °F
| [storage temp. ]
Sealed in dry,2-8°C | [form ]
liquid | [pka]
1.35±0.20(Predicted) | [color ]
Dark brown | [InChI]
InChI=1S/C6H8N2S/c1-5-3-4-7-6(8-5)9-2/h3-4H,1-2H3 | [InChIKey]
UCERVHYBSTYCQS-UHFFFAOYSA-N | [SMILES]
C1(SC)=NC=CC(C)=N1 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to yellow to red liquid | [Uses]
4-Methyl-2-(methylthio)pyrimidine is used as a reagent to prepare pyrazolopyrimidines and pyrazolotriazines, both of which display potent activity against herpes viruses. 4-Methyl-2-(methylthio)pyrimidine is also used as a starting material to synthesize 4-substituted-2-aminopyrimidines (e.g. 2-amino-4-ethylpyridine [A609500]), novel c-Jun N-terminal kinase (JNK) inhibitors. | [Synthesis]
To an aqueous (120 mL) solution of NaOH (7.46 g, 186.4 mmol) under argon atmosphere,
4-methylpyrimidine-2-thiolate (13.78 g, 84.7 mmol) was added, followed by the dropwise addition of
into iodomethane (13.23 g, 93.2 mmol). The solution was stirred at ro |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-37/38-41 | [Safety Statements ]
26-39 | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29335990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
|
|