| Identification | Back Directory | [Name]
Tosufloxacin p-Toluenesulfonate Hydrate | [CAS]
1400591-39-0 | [Synonyms]
T-3262 Tosylate Hydrate
A-61827 tosylate hydrate
Tosufloxacin (tosylate hydrate)
Tosufloxacin p-Toluenesulfonate Hydrate
1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate, hydrate (1:1:) | [Molecular Formula]
C19H15F3N4O3.C7H8O3S | [MDL Number]
MFCD01711971 | [MOL File]
1400591-39-0.mol | [Molecular Weight]
576.544 |
| Hazard Information | Back Directory | [Uses]
Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2]. | [Definition]
ChEBI: A racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate hydrate. | [in vivo]
Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2]. | Animal Model: | Male Slc:ICR mice infected with S. aureus[2] | | Dosage: | 1.27-2.15 mg/kg | | Administration: | Oral gavage; 1.27-2.15 mg/kg; once | | Result: | Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL. |
| Animal Model: | Male Slc:ICR mice infected with E. coli[2] | | Dosage: | 0.16-0.30 mg/kg | | Administration: | Oral gavage; 0.16-0.30 mg/kg; once | | Result: | Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL. |
| Animal Model: | Male Slc:ICR mice infected with P. aeruginosa[2] | | Dosage: | 7.66-13.39 mg/kg | | Administration: | Oral gavage; 7.66-13.39 mg/kg; once | | Result: | Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL. |
| [IC 50]
Quinolone | [storage]
Store at -20°C | [References]
[1] Chu DT, et al. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. PMID:2100244
[2] Fujimaki K, et al. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827-33. DOI:10.1128/AAC.32.6.827 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
TCI Chemicals
|
| Tel: |
021-67121386, 800-988-0390 |
| Website: |
www.tcichemicals.com |
|